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Long Haul Covid

We have ALL your misinformation, plus some TRUE FACTS and SCIENCE.
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RTH10260
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Re: Long Haul Covid

#76

Post by RTH10260 »

"it's just the common flu...." :twisted:
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Lani
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Long Haul Covid

#77

Post by Lani »

‘We are in trouble’: Study raises alarm about impacts of long covid
https://www.washingtonpost.com/health/2 ... -scotland/

While the article reports on long covid in the US, the important information is based on Scotland statistics where everyone has health care.
“It’s one more well-conducted, population-level study showing that we should be extremely concerned about the current numbers of acute infections,” said David Putrino, director of rehabilitation innovation for the Mount Sinai Health System in New York. “We are in trouble.”
... The Covid in Scotland Study, which included a control group, was able to pinpoint which symptoms were linked to covid, Pell said.

“Those who had covid were significantly more likely to get 24 of the 26 symptoms studied compared to the never-infected general population,” she said. For example, those who were infected were 3½ times more likely to be breathless.
Long hauler symptoms range widely from person to person. In the Scottish study, the most commonly reported symptoms included breathlessness, palpitations, chest pain and “brain fog,” or reduced mental acuity.

Symptoms were worst among people who were sick enough to be hospitalized during the acute infection — a fact that does little to quell experts’ concerns.

“It has always been the case that those who are sicker are more likely to have long-term sequelae,” Putrino said. “What is frightening is that the mild cases by far outnumber the severe, so even a small percentage of mild cases going on to develop long-term sequelae is a massive public health concern.”
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MN-Skeptic
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Long Haul Covid

#78

Post by MN-Skeptic »

Could Paxlovid treat long Covid? Major new study aims to find out

:snippity:
Geng and her colleagues at Stanford Medicine have embarked on the first clinical trial to test whether Pfizer's Paxlovid may help alleviate symptoms of ongoing fatigue, weakness or brain fog. The antiviral has already been shown to be effective in protecting against severe illness if used within five days of getting sick. It prevents the virus from replicating inside the body.
:snippity:
Researchers hypothesize that Paxlovid may be able to make a measurable impact on that leftover virus, if that is indeed what causes long Covid.

Stanford's study aims to enroll 200 adults who have had long Covid symptoms for at least three months, without a recent diagnosis of the disease.

Half of them will get the actual drug, while the others will get a placebo. While Paxlovid is generally given for five days, this study will have participants take it for 15. This is meant, in part, to address the possibility that the drug needs more time to work well. Many patients newly diagnosed with Covid have reported rebound symptoms after their typical five-day treatment course.

Results are expected sometime next year.
The final paragraph says that a leading long Covid researcher "suspects that the drug may not be useful after someone has already been suffering for a while." I sure hope he's wrong and that there is relief for these awful, lingering symptoms. At least they're doing tests now, so that's a good thing.
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Lani
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Long Haul Covid

#79

Post by Lani »

One theory know is that pieces of the virus continue in the body. Famotidine and loratadine are being trialed. However, the challenge is that when the damaged is done, neither will help. I'm guessing (when means nothing) that if these drugs are helpful, people should take them while they are recovering. Waiting for problems to appear would be too late.
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sugar magnolia
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Long Haul Covid

#80

Post by sugar magnolia »

Interesting that they are using the same 2 drugs for long covid that are used for chemo patients. Were it not for the high-dose Claritin regimen I was on during my chemo, I would have been very close to, or completely bed ridden. I continue to take it for the side effects of my cholesterol meds, and suggested it to my mother for her West Nile symptoms. She checked with her PCP and has just started it for her lingering symptoms.
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Long Haul Covid

#81

Post by Tiredretiredlawyer »

Sugar: I continue to take it for the side effects of my cholesterol meds, and suggested it to my mother for her West Nile symptoms.
Which drug are you taking for cholesterol and which for relief from cholesterol drug? I just started taking CO Q10 for simvastatin caused leg cramps.
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sugar magnolia
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#82

Post by sugar magnolia »

Tiredretiredlawyer wrote: Sat Nov 26, 2022 9:46 am
Sugar: I continue to take it for the side effects of my cholesterol meds, and suggested it to my mother for her West Nile symptoms.
Which drug are you taking for cholesterol and which for relief from cholesterol drug? I just started taking CO Q10 for simvastatin caused leg cramps.
Lipitor for the cholesterol and Claritin for the Lipitor side effects. Mostly leg muscle pain.
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#83

Post by Tiredretiredlawyer »

Thanks!
"Mickey Mouse and I grew up together." - Ruthie Tompson, Disney animation checker and scene planner and one of the first women to become a member of the International Photographers Union in 1952.
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MN-Skeptic
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Long Haul Covid

#84

Post by MN-Skeptic »

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Lani
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#85

Post by Lani »

More data! However, we still don't know the best treatments to help people w/long covid.

Heart disease after COVID: what the data say
Some studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up. Researchers are starting to pin down the frequency of these issues and what is causing the damage.
https://www.nature.com/articles/d41586-022-02074-3
Studies indicate that the coronavirus is associated with a wide range of lasting problems, such as diabetes, persistent lung damage and even brain damage. As with these conditions, Al-Aly says that the cardiovascular issues that occur after a SARS-CoV-2 infection can decrease a person’s quality of life over the long term. Treatments do exist for these problems, “but they are not curable conditions”, he adds. :snippity:
Could tiny blood clots cause long COVID’s puzzling symptoms?
Scientists debate evidence for a micro-clot hypothesis that has some people pursuing potentially risky treatments.
:snippity: Pretorius first saw these strange, densely matted clots in the blood of people with a clotting disorder2, but she and Kell have since observed the phenomenon in a range of conditions1 — diabetes, Alzheimer’s disease and Parkinson’s disease, to name a few. But the idea never gained much traction, until now.

When the pandemic hit in 2020, Kell and Pretorius applied their methods almost immediately to people who had been infected with SARS-CoV-2. “We thought to look at clotting in COVID, because that is what we do,” Pretorius says. Their assay uses a special dye that fluoresces when it binds to amyloid proteins, including misfolded fibrin. Researchers can then visualize the glow under a microscope. The team compared plasma samples from 13 healthy volunteers, 15 people with COVID-19, 10 people with diabetes and 11 people with long COVID3. For both long COVID and acute COVID-19, Pretorius says, the clotting “was much more than we have previously found in diabetes or any other inflammatory disease”. In another study4, they looked at the blood of 80 people with long COVID and found micro-clots in all of the samples.

So far, Pretorius, Kell and their colleagues are the only group that has published results on micro-clots in people with long COVID.But in unpublished work, Caroline Dalton, a neuroscientist at Sheffield Hallam University’s Biomolecular Sciences Research Centre, UK, has replicated the results. She and her colleagues used a slightly different method, involving an automated microscopy imaging scanner, to count the number of clots in blood. The team compared 3 groups of about 25 individuals: people who had never knowingly had COVID-19, those who had had COVID-19 and recovered, and people with long COVID. All three groups had micro-clots, but those who had never had COVID-19 tended to have fewer, smaller clots, and people with long COVID had a greater number of larger clots. The previously infected group fell in the middle. The team’s hypothesis is that SARS-CoV-2 infection creates a burst of micro-clots that go away over time. In individuals with long COVID, however, they seem to persist.

Dalton has also found that fatigue scores seem to correlate with micro-clot counts, at least in a few people. That, says Dalton, “increases confidence that we are measuring something that is mechanistically linked to the condition”.
:snippity:
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#86

Post by AndyinPA »

https://www.nbcnews.com/health/health-n ... rcna116871
More than three years into the pandemic, the millions of people who have suffered from long Covid finally have scientific proof that their condition is real.

Scientists have found clear differences in the blood of people with long Covid — a key first step in the development of a test to diagnose the illness.

The findings, published Monday in the journal Nature, also offer clues into what could be causing the elusive condition that has perplexed doctors worldwide and left millions with ongoing fatigue, trouble with memory and other debilitating symptoms.

The research is among the first to prove that "long Covid is, in fact, a biological illness," said David Putrino, principal investigator of the new study and a professor of rehabilitation and human performance at the Icahn School of Medicine at Mount Sinai in New York.
"Choose your leaders with wisdom and forethought. To be led by a coward is to be controlled by all that the coward fears… To be led by a liar is to ask to be told lies." -Octavia E. Butler
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much ado
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Long Haul Covid

#87

Post by much ado »

Thanks for this. Our son is interested in this topic.
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Lani
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Long Haul Covid

#88

Post by Lani »

Ditto. That was very interesting.
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#89

Post by AndyinPA »

https://www.theguardian.com/society/202 ... rier-study
Long Covid ‘brain fog’ may be due to leaky blood-brain barrier, study finds

From forgetfulness to difficulties concentrating, many people who have long Covid experience “brain fog”. Now researchers say the symptom could be down to the blood-brain barrier becoming leaky.

The barrier controls which substances or materials enter and exit the brain. “It’s all about regulating a balance of material in blood compared to brain,” said Prof Matthew Campbell, co-author of the research at Trinity College Dublin.

“If that is off balance then it can drive changes in neural function and if this happens in brain regions that allow for memory consolidation/storage then it can wreak havoc.”

Writing in the journal Nature Neuroscience, Campbell and colleagues report how they analysed serum and plasma samples from 76 patients who were hospitalised with Covid in March or April 2020, as well 25 people before the pandemic.

Among other findings, the team discovered that samples from the 14 Covid patients who self-reported brain fog contained higher levels of a protein called S100β than those from Covid patients without this symptom, or people who had not had Covid.

This protein is produced by cells within the brain, and is not normally found in the blood, suggesting these patients had a breakdown of the blood-brain barrier.
"Choose your leaders with wisdom and forethought. To be led by a coward is to be controlled by all that the coward fears… To be led by a liar is to ask to be told lies." -Octavia E. Butler
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Rolodex
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Long Haul Covid

#90

Post by Rolodex »

I also read recently that they're seeing issued in the placentas of people with long covid. Excellent - the GOP will find a way to punish women who lose their pregnancies because of placenta issues.
Do the right thing. It will gratify some people and astonish the rest. - Mark Twain
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Long Haul Covid

#91

Post by RTH10260 »

‘Alarming’ rise in Americans with long Covid symptoms
CDC data shows nearly 18m people could be living with long Covid even as health agency relaxes isolation recommendations

Melody Schreiber
Fri 15 Mar 2024 12.00 CET

Some 6.8% of American adults are currently experiencing long Covid symptoms, according to a new survey from the US Centers for Disease Control and Prevention (CDC), revealing an “alarming” increase in recent months even as the health agency relaxes Covid isolation recommendations, experts say.

That means an estimated 17.6 million Americans could now be living with long Covid.

“This should be setting off alarms for many people,” said David Putrino, the Nash Family Director of the Cohen Center for Recovery From Complex Chronic Illness at Mount Sinai. “We’re really starting to see issues emerging faster than I expected.”

When the same survey was conducted in October, 5.3% of respondents were experiencing long Covid symptoms at the time.

The 1.5 percentage-point increase comes after the second-biggest surge of infections across the US this winter, as measured by available wastewater data.

More than three-quarters of the people with long Covid right now say the illness limits their day-to-day activity, and about one in five say it significantly affects their activities – an estimated 3.8 million Americans who are now experiencing debilitating illness after Covid infection.

A new study found that thousands of people in the UK may not be working because of long Covid. Americans have also missed work at higher rates since the pandemic started.

The rate of adults currently experiencing long Covid has not been this high since November 2022; the greatest height since CDC began tracking the illness was 7.6% in June and July 2022.

The “estimates represent just a snapshot in time”, making it difficult to identify the role of different factors like recent surges, vaccination rates, new variants and survey methods, said Dave Daigle, a spokesperson for the CDC.

The most recent Household Pulse survey took place between 9 January and 5 February, and asked respondents if their Covid symptoms were currently lasting three months or more. Because long Covid symptoms, by definition, appear or linger after infection, the rate could continue to rise in coming months even as infections fall from the winter peak.

The next round of survey results are expected at the end of this month.



https://www.theguardian.com/world/2024/ ... mptoms-cdc
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