p0rtia wrote: ↑
Thu Jun 13, 2019 2:41 pm
Hurtzi wrote: ↑
Thu Jun 13, 2019 7:24 am
So I guess you know what you are talking about.
I do as well, having my experiences with binge eating for nearly 60 years now.
Maybe pOrtia will start a thread as proposed by herself.
This post is an answer to Roadscholar and not Foggy
I'm waffling, I admit. I'm just not sure I want to take it on. Yes, I know I would have no actual duty to respond to posts repeating destructive stereotypes, but this is a topic I care passionately about, so I would want to. Do I have time for that? And the psychic energy? Because the truth is I get angry when I hear the ignorance and the superiority, even from friends.
What I really wanted was a thread to discuss the very cool weight management info that is coming to a boil these days: Not only IF and its cousins, but the hormonal approach (featuring insulin resistance/response), and what I believe to be the horribly destructive "low fat" protocol we've been fed for the past fifty years. I so appreciate the brains here, and it is such an interesting subject.
Is that possible?
Oh, and hey there, Hurtzi!
Sixty years beats my 40. It's been four years since became a binge-er in remission, as I like to call it, but once a binge-er always a binge-er, at least in the head.
It's a fascinating area, and we are just now getting to the real centers.
For ages scientific research, especially cancer, focussed on DNA that coded for proteins and call everything else "junk" DNA. It was an absurd idea considering that meant 92%-98% of the chromosomes did nothing. Now, it is generally accepted it manufactures the RNA regulatory machinery that is often referred to as epigenetics. As an evolutionary molecular biology guy with degrees in the 80's, almost nothing even vaguely resembles what was taught then.
The academic inertia is still a restraint, but in my view, this is why the 30 year War on Cancer hasn't won many battles. At the heart of the metabolic disease family is epigenetics with very strong indications that early epigenetic markers (even during pregnancy ) can have effects decades later.
One area I became aware of, because of a friend asking me to look at traumatic head injury treatments, was some studies on Tibetan Sherpas and their high altitude adaptation. They have some SNP's that I had seen in Fibromyalgia's global-wide-association-studies. The Sherpas' children express diabetes at very different rates as well, and it appears related to peroxide genes (PPAR ) activated by the endoplasmic reticulum's Integrated Stress Response system that is involved in the Unfolded Protein Response (think Alzheimer's) and the area that modulates pain adaptation (think Fibromyalgia) invoking the only place the 23rd Amino Acid (yes, we are taught 20...), Hypusine, is used in translational regulation. Altered tRNA and ribosomes produce different sets of protein than normal (from the same coding).
This is evolutionarily conserved from eukaryotes in response to changes in environment, and this set is hypoxia and cold shock related.(in fact cold water immersion can cause high altitude adaptions response).
But, across the board in diabetes--(gestational, DBII, etc ) this Elf factor is involved.
I don't know how true this is, but it seems we are finally poised for some medical progress after long stagnation.
Vaccines, antibiotics, and surgery (trauma care) are great, but there has been, no offense to anyone, less than remarkable progress elsewhere. And, I just want rap my shoe on the table and wake all the different research disciplines up, with the big pharma honchos present (skipping a nail manicure- no offense to well groomed men), and point out exhibits A,B, C, D, etc, explain "Streetlight Effect," and say, "Look where the keys are!" to finally make some research money go where it so obviously would give enormous benefits.
And, there's existing FDA approved medications with off label uses.
For Fibromyalgia, some studies have shown Metformin to have 60% -80% reduction in pain and tender spots at 4 weeks on. For these poor souls the phrase "There's no cure for that." Is not only disheartening, but I believe it's wrong.
But we know where the epigenetic markers are now and need to reset them-- demethylate them on a selective basis. It is known how to do this in a less selective manner, but that is reckless and has potentially large negative consequences.
With CRISPr, and the unique amino acid and pathways, narrowing this down to a drug target could be a game changer in ALL chronic diseases-- even those like Parkinson's and Huntington's and Lupus which have strong genetic associations (but only express later in life).
But, no one has the time to read all this barrage of info with regular time demands. I barely have a grip on it, and I've reviewed over 3000 papers.
Speaking of which, the one's I've marked as important (by no real system), I have in a sortable spreadsheet and there's 300 or so relevant Fibromyalgia.
I really haven't gone into the glycoproteins (gehrlin, lepton, etc) as that's one I want to wrap together with the endocannabinoids( and an evolution of regulatory systems hypothesis that's rumbling around ), but there are a hundred or so of those (the spread sheet is 5600 lines but it boils down to around 2000).
I can't claim anything of value to it, except its the path my " latent inhibition" semi-schizophrenic brain took. I can cloud-share a search on a topic if wanted. I haven't checked it thoroughly to be assured that a google search for "Lesbian Midget Nuns" hasn't slipped through the filters, and I don't want to embarrass my parrots with whom I share the computer (that's my story and I'm sticking to it).
And, regarding all the opinions. We are all wrong. The objective is to be "less wrong" tomorrow.