New Diseases - Coronavirus

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Suranis
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Re: New Diseases - Coronavirus

#3301

Post by Suranis »

SOOOOOooooooo.... Turns out Chloroquine does fuck all.

The researcher who claimed it helped has about as reliable a record as the autism=vaccines guy, and is well known for flawed research that uses dodgy data etc. A correctly conducted Chinese study that showed chloroquine did nothing was ignored because this flawed western one said it worked.

But hey who cares about those lupus, malaria, and Chloroquine poisoning patients, huh? And we can be sure that people will be saying this is the Governments covering up the cure till the end of time. Gotta stockpile just in case!

The difference between the Middle Ages, and the Age of the Internet, is that in the Middle Ages no-one thought the Earth was flat.

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Re: New Diseases - Coronavirus

#3302

Post by Volkonski »

Hadn't thought about this.

US private health insurance companies clog system amid Covid-19 pandemic

https://www.theguardian.com/us-news/202 ... -hospitals
As Augie Lindmark, a resident physician at Yale University prepared for an onslaught of Covid-19 patients last week, he noticed something at his hospital: there were still patients without the virus, completely stable, in the beds.

These patients, many of whom should have been moved to a rehab facility or released, were stuck waiting until their private health insurance company authorized the next steps, which can take days.

Usually, the prior authorization process is an expected inefficiency at Yale, and most other American hospitals. But with thousands of Covid-19 patients being admitted every day across the country, and a critical shortage of hospital beds, that red tape now carries much more weight.

“Any sort of slowing in the health system has dire consequences,” Lindmark said.
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RVInit
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Re: New Diseases - Coronavirus

#3303

Post by RVInit »

RTH10260 wrote:
Thu Mar 26, 2020 10:48 am
RoadScholar wrote:
Thu Mar 26, 2020 9:51 am
James Dyson designed a new ventilator in 10 days. He's making 15,000 for the pandemic fight


https://www.cnn.com/2020/03/26/tech/dys ... index.html
Where is the Buy American production at this time ?

#MAGA :sarcasm:
Exactly. It has not escaped my notice that the US has not been in the lead in ANY way, shape, or form, or in any area, whether it be testing, manufacturing equipment and/or supplies or anything else.

It's a sad day for America when the POTUS is asking other countries for help, supplies, and equipment. And, at the same time, offering tests that we don't even have for ourselves to countries that are undeniably unfriendly to the US. The only thing missing is POTUS praising Putin and offering to send Russia all the ventilators he can get his tiny little hands on.
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Dr. Kenneth Noisewater
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Re: New Diseases - Coronavirus

#3304

Post by Dr. Kenneth Noisewater »

Volkonski wrote:
Thu Mar 26, 2020 2:49 pm
Within a day the US will report more confirmed cases than Italy. Shortly after than the US will have more than China. Italy new deaths per day back over 700. :(

ScreenHunter_186 Mar. 26 13.45.jpg
I'd say by this weekend we'll be #1 with cases in the US.

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Slim Cognito
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Re: New Diseases - Coronavirus

#3305

Post by Slim Cognito »

RVInit wrote:
Thu Mar 26, 2020 3:08 pm


Exactly. It has not escaped my notice that the US has not been in the lead in ANY way, shape, or form, or in any area, whether it be testing, manufacturing equipment and/or supplies or anything else.

It's a sad day for America when the POTUS is asking other countries for help, supplies, and equipment. And, at the same time, offering tests that we don't even have for ourselves to countries that are undeniably unfriendly to the US. The only thing missing is POTUS praising Putin and offering to send Russia all the ventilators he can get his tiny little hands on.
I'd bet the farm his plan was to sell those tests (that we don't even have for ourselves) at an inflated price and brag about how much money he made.
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Sam the Centipede
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Re: New Diseases - Coronavirus

#3306

Post by Sam the Centipede »

Suranis wrote:
Thu Mar 26, 2020 2:50 pm
SOOOOOooooooo.... Turns out Chloroquine does fuck all.
I watched a live stream Q&A on March 25th by the London School of Hygeine and Tropical Medicine (part of the University of London, I think). The LSHTM has a free course running now on FutureLearn about Covid-19/SARS-CoV-2.

There was a question about chloroquine (? or a similar name, but I think they're all referring to the same drug, or a variation thereof). I was surprised at the answers from the professors, who took a fairly benevolent "wait and see" line on it. I was expecting a much firmer "there is no evidence yet" followed by a hedging of bets. Of course, it's possible that the two professors (one had a chair in international health policy, the other is anthropology and risk assessment etc.) were outside their comfort zone on specific drug issues, hence the non-committal answers.

From an naive outsider's point of view, it would seem odd if a drug active against a protozoan blood parasite should be effective against a respiratory virus: different systems in the human body affected by vastly different organisms.

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Volkonski
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Re: New Diseases - Coronavirus

#3307

Post by Volkonski »

Orleans, Louisiana, US
Confirmed: 997
Deaths: 46

Jefferson, Louisiana, US
Confirmed: 458
Deaths: 12

Whole state
Confirmed: 2,305
Deaths: 83
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DejaMoo
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Re: New Diseases - Coronavirus

#3308

Post by DejaMoo »

Sam the Centipede wrote:
Thu Mar 26, 2020 3:15 pm
Suranis wrote:
Thu Mar 26, 2020 2:50 pm
SOOOOOooooooo.... Turns out Chloroquine does fuck all.
I watched a live stream Q&A on March 25th by the London School of Hygeine and Tropical Medicine (part of the University of London, I think). The LSHTM has a free course running now on FutureLearn about Covid-19/SARS-CoV-2.

There was a question about chloroquine (? or a similar name, but I think they're all referring to the same drug, or a variation thereof). I was surprised at the answers from the professors, who took a fairly benevolent "wait and see" line on it.
I don't have the articles handy, but there have been a few stories reporting anecdotal evidence from some doctors at a few hospitals that tried the dual-drug treatment on some patients and saw marked improvement, to the point where they decided it was worth going ahead with it as a treatment on more patients.

Everyone knows anecdotes are not data - but it may also be why some are not yet ready to dismiss it outright. Desperate times, desperate measures.

Personally, considering the potential side effects of the anti-malarial drug, I would have to be desperate to use it. I already have very poor vision, not interested in possibly losing what I have.
I've heard this bull before.

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Re: New Diseases - Coronavirus

#3309

Post by Volkonski »

Ed Belongia MD
@EdBelongia
·
1h
Report from
@UChicago
economists: "Moderate social distancing would save 1.7M lives between March 1 and Oct 1...We find that the mortality benefits of social distancing are over $8 trillion or $60,000 per US household."Downwards arrow
https://papers.ssrn.com/sol3/papers.cfm ... id=3561244
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Re: New Diseases - Coronavirus

#3310

Post by Volkonski »

Taylor Goldenstein
@taygoldenstein
BREAKING:
@GovAbbott
issues new executive order mandating that anyone entering Texas from New York, New Jersey, Connecticut or the city of New Orleans will be subject to a mandatory self-quarantine for 14 days or duration of stay in Texas, whichever is shorter. Enforced by
@TxDPS

Abbott: Failure to comply with this ordinance is a crime $1,000 fine or 180 days in jail or both.

"This is intended simply to achieve the goals that have been articulated by the CDC + by the White House organization focused on reducing the spread of the coronavirus in the U.S."

Abbott clarifies this is only for travel by air
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Re: New Diseases - Coronavirus

#3311

Post by Volkonski »

CNN Breaking News
@cnnbrk
·
1m
New Hampshire's governor has issued a stay-at-home order starting at midnight Friday. The order will last until the end of May. https://cnn.it/2QPBSRX
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Re: New Diseases - Coronavirus

#3312

Post by Volkonski »

Regarding chloroquine, that French study appears to be highly dubious.

As COVID19 pandemic rages on, French microbiologist Didier Raoult offers a cure. President Trump is convinced, but is Raoult's research reliable, here and in general?

https://forbetterscience.com/2020/03/26 ... -covid-19/
Coronavirus COVID-19 pandemic is about to be stopped by a stroke of a French genius. The charismatic Didier Raoult, director of the Research Unit in Infectious and Tropical Emergent Diseases (URMITE) in Marseille has found a cure: the humble chloroquine, cheap unpatented substance used to treat malaria and autoimmune diseases lupus and rheumatism. The substance so far failed in all antiviral therapies, but this didn’t prevent Raoult from deciding that chloroquine can cure corona virus infections, serious side effects notwithstanding. To prove that, Raoult treated 26 patients at his institution with the derivative hydroxychloroquine, alone and in combination with the antibiotic (meaning antibacterial!) drug azithromycine. The study was not randomised, ethically approved only after it already began, and it was not really controlled: the 16 control patients were treated in different clinics.

After some adjustments (patients removed, data points guessed), a preprint was published simultaneously with a paper in a peer reviewed journal Raoult basically controls. Next, a lawyer with whom Rault partnered with pitched the miracle cure to Fox News, which is the TV channel US president Donald Trump watches all day to get all his information.

:snippity:

In fact, the authors never showed the results of day 14 either. They also refused to share their secondary endpoint data, namely “the clinical effectiveness of treatment on time to apyrexia, normalization of respiratory rate, and average length of hospital stay and mortality”. Basically, it is none of anyone’s business to know if the therapy had any clinical benefit for the patients.

:snippity:

Some control patients were tested only every second day, afterwards guessed to be positive, some were not tested at all on day 0, as a PubPeer commented noted. And then the authors simply changed the results in control patients between the “in press” and the final paper version, as another PubPeer uses observed:
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Re: New Diseases - Coronavirus

#3313

Post by Volkonski »

Martín Macías Jr.
@_mxmmedia
·
59m
Breaking: LA County reports big surge in new cases and nearly doubled total deaths from the novel coronavirus. Public Health Director Barbara Ferrer reports 9 additional deaths due to Covid-19 --- 21 total. Also, 421 new cases bringing total number of confirmed cases to 1,216.
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Re: New Diseases - Coronavirus

#3314

Post by Volkonski »

We're number 1. :(

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Sugar Magnolia
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Re: New Diseases - Coronavirus

#3315

Post by Sugar Magnolia »

And we didn't even have to wait for the weekend.

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Re: New Diseases - Coronavirus

#3316

Post by Volkonski »

Oklahoma nursing facilities.
Bonnie Campo
@bonniecampo
·
1m
BREAKING: IMPORTANT UPDATED INFORMATION ON THE SITUATION AT GRACE SKILLED NURSING AND THERAPY NORMAN!
Seven additional residents in the home have tested positive for COVID-19 for a total of nine. Two have died as of yesterday.
@NEWS9
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Re: New Diseases - Coronavirus

#3317

Post by DejaMoo »

Minnesota doctor engaged in FDA-approved Hydroxychloroquine trials lacks volunteers
https://abcnews.go.com/US/minnesota-doc ... d=69793007
A Minnesota doctor is calling on healthcare workers and people who have tested positive for COVID-19 and are showing early symptoms of infection to participate in two of the first trials of the malaria drug Hydroxychloroquine to treat coronavirus patients.

Dr. David Boulware, an infectious disease specialist from the University of Minnesota, is one of the first doctors to receive approval from the Food & Drug Administration (FDA) to conduct a pair of clinical trials of the drug, which has been heavily promoted by President Trump as a potential antidote to the outbreak.

The first trial will be comprised primarily of healthcare workers and others with a high risk of exposure to the virus, while the second will be open to the general public who have already tested positive for COVID-19. Hydroxychloroquine is being studied both as a way to prevent COVID-19 infection as well as a way to treat people who are already sick.

But one of his biggest problems? He needs volunteers, and lots of them. Boulware is seeking 1500 volunteers for the first trial, but in the week since he obtained FDA approval, he has managed to recruit only 411. Recruitment for the second trial, which is also seeking 1500 volunteers, is going even slower. As of this writing, he has only 25.

Researchers will send some participants Hydroxychloroquine (and others a placebo) in the mail and monitor their progress remotely through daily questionnaires.

According to Boulware, healthcare workers and others with a high risk of exposure to the virus, as well as anyone who has recently tested positive (within four days of the test), can learn more about the trials by emailing covid19@umn.edu.

As his trials begin, Boulware and his team remain cautiously optimistic about hydroxychloroquine’s potential.

“We should have answers to these questions within three to four weeks,” Boulware said.
I've heard this bull before.

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Re: New Diseases - Coronavirus

#3318

Post by jemcanada »

Sam the Centipede wrote:
Thu Mar 26, 2020 3:15 pm
Suranis wrote:
Thu Mar 26, 2020 2:50 pm
SOOOOOooooooo.... Turns out Chloroquine does fuck all.
I watched a live stream Q&A on March 25th by the London School of Hygeine and Tropical Medicine (part of the University of London, I think). The LSHTM has a free course running now on FutureLearn about Covid-19/SARS-CoV-2.

There was a question about chloroquine (? or a similar name, but I think they're all referring to the same drug, or a variation thereof). I was surprised at the answers from the professors, who took a fairly benevolent "wait and see" line on it. I was expecting a much firmer "there is no evidence yet" followed by a hedging of bets. Of course, it's possible that the two professors (one had a chair in international health policy, the other is anthropology and risk assessment etc.) were outside their comfort zone on specific drug issues, hence the non-committal answers.

From an naive outsider's point of view, it would seem odd if a drug active against a protozoan blood parasite should be effective against a respiratory virus: different systems in the human body affected by vastly different organisms.
I just signed up for this MOOC yesterday.

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Re: New Diseases - Coronavirus

#3319

Post by Jeffrey »

Puerto Rico lockdown plus curfew extended to April 12. Grocery stores and some other things closed Sunday, used to stay open. Cars with even numbered plates and odd numbered plates can go to the grocery store/pharmacy on alternating days. And curfew starts at 7 instead of 9 pm.

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Re: New Diseases - Coronavirus

#3320

Post by pipistrelle »

Hydroxychloroquine
Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used. Because these drugs have limited ability to prevent joint damage on their own, their use should probably be limited to patients with very mild, seronegative, and nonerosive disease. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine.

Mechanism:

The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system.
Dosage: Hydroxychloroquine (Plaquenil®) is the drug of choice among antimalarials. Chloroquine is not commonly used because of greater toxicity on the eye. The usual dose of Plaquenil is 400mg/day but 600mg/day is sometimes used as part of an induction regimen. It may be prescribed as a single daily dose or in divided doses twice per day.

Usual Time to Effect:

A period of 2 to 4 months is usual. Most agree that if a patient shows no response after 5-6 months that this should be considered a drug failure.
From Johns Hopkins Arthritis. Have no idea why/how this would work.

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Re: New Diseases - Coronavirus

#3321

Post by Whatever4 »

Jeffrey wrote:
Thu Mar 26, 2020 5:47 pm
Puerto Rico lockdown plus curfew extended to April 12. Grocery stores and some other things closed Sunday, used to stay open. Cars with even numbered plates and odd numbered plates can go to the grocery store/pharmacy on alternating days. And curfew starts at 7 instead of 9 pm.
What about non-drivers?
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Sugar Magnolia
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Re: New Diseases - Coronavirus

#3322

Post by Sugar Magnolia »

Whatever4 wrote:
Thu Mar 26, 2020 6:17 pm
Jeffrey wrote:
Thu Mar 26, 2020 5:47 pm
Puerto Rico lockdown plus curfew extended to April 12. Grocery stores and some other things closed Sunday, used to stay open. Cars with even numbered plates and odd numbered plates can go to the grocery store/pharmacy on alternating days. And curfew starts at 7 instead of 9 pm.
What about non-drivers?
They have to walk.

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Whatever4
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Re: New Diseases - Coronavirus

#3323

Post by Whatever4 »

Sugar Magnolia wrote:
Thu Mar 26, 2020 6:17 pm
Whatever4 wrote:
Thu Mar 26, 2020 6:17 pm
Jeffrey wrote:
Thu Mar 26, 2020 5:47 pm
Puerto Rico lockdown plus curfew extended to April 12. Grocery stores and some other things closed Sunday, used to stay open. Cars with even numbered plates and odd numbered plates can go to the grocery store/pharmacy on alternating days. And curfew starts at 7 instead of 9 pm.
What about non-drivers?
They have to walk.
But which day?
"[Moderate] doesn't mean you don't have views. It just means your views aren't predictable ideologically one way or the other, and you're trying to follow the facts where they lead and reach your own conclusions."
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Sugar Magnolia
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Re: New Diseases - Coronavirus

#3324

Post by Sugar Magnolia »

Whatever4 wrote:
Thu Mar 26, 2020 6:18 pm
Sugar Magnolia wrote:
Thu Mar 26, 2020 6:17 pm
Whatever4 wrote:
Thu Mar 26, 2020 6:17 pm


What about non-drivers?
They have to walk.
But which day?
All of them. You can just point to any random car in the lot and say "that one's mine."

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Re: New Diseases - Coronavirus

#3325

Post by Sterngard Friegen »

Volkonski wrote:
Thu Mar 26, 2020 4:29 pm
Regarding chloroquine, that French study appears to be highly dubious.

As COVID19 pandemic rages on, French microbiologist Didier Raoult offers a cure. President Trump is convinced, but is Raoult's research reliable, here and in general?

https://forbetterscience.com/2020/03/26 ... -covid-19/
The French physician involved in this apparently bogus study looks like a French version of Trump's physician who wrote that Trump was the healthiest person ever to run for POTUS.

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