Danraft wrote: ↑
Wed Dec 25, 2019 7:28 am
Just did a quick skim of the last page or so because I'd hinted to P0rtia that I'd share some of the research findings that have potentially large implications in weight management and she told me about this thread.
I do an inordinate amount of scientific journal research, and the word of the week (related to this topic) would be "Allostasis", which is a refinement of the concept of homeostasis.
In homeostasis, certain cellular environmental variables (ie: body temperature, blood pH, oxygen and CO2 levels, etc) are considered to kept in narrow parameters by regulatory methods activated when the variable starts to go " out-of-bounds". For instance, high body temperature activates the secretion of sweat to lose heat through evaporative cooling.
The concept of allostasis arose in 1988 and includes that an organism's various overlapping regulatory systems is actually often acting in a predictive manner (think Pavlonian production of saliva before food is present) and also accounts for manners of dysregulation.
Related to weight management would be adipostasis which, as the name implies is the system for fat storage management.
1. The amount of fat the body has in reserve is monitored by cellular and nerve signals from each fat storage area.
2. The total amount of "target fat storage" varies by environmental needs (nutrient availability, etc), stress events (by several mechanisms), life stage (age, pregnancy, etc), and other cues.
And, this fascinates me.... When the nerves responsible for carrying the signal of how much fat (and of what type) is stored in that region are snipped or chemically blocked, two things happen.
A. The amount of fat stored in that disconnected region increases dramatically (local effect).
B. The total amount of fat stored in other fat storage locations increases to replace the amount of now "missing" fat storage (global effect).
Holy crap. The implications are important. Set aside the perhaps most important part of "how can we change the target fat storage amount?" And, take a mental walk with me.
This means the efficiency of feedback is potentially quite important. And, this efficiency seems to be variable based on adaptation responses and dysfunction. It also explains, in combination with the global target of adipose storage why weight loss can be a struggle with yo-yo dieat effects.
Exercise not only burns calories, but increases blood flow to areas -- and that also supports neural function. And, nerves can be pinched or lose efficiency that could be restored with range of motion activities like yoga, Pilate's, massage and other techniques.
At least, that's my take on it...thoughts?